Michael Bartlett, Ph.D.

Pharmaceutical and Biomedical Sciences
Professor and Director, B.S. Program
Associate Dean for Science Education, Research and Technology

Pharmaceutical and Biomedical Sciences

  • Education

    Ph.D. Analytical Chemistry, Georgia Institute of Technology 1994

    B.S. Chemistry, North Carolina State University 1990

  • Honors, Awards, and Achievements
    • 2013 Outstanding Manuscript in Analysis and Pharmaceutical Quality from the American Association for Pharmaceutical Scientists
    • 2011 Elected Fellow of the American Association for Pharmaceutical Scientists
    • Research Achievement Award in Analysis and Pharmaceutical Quality from the American Association for Pharmaceutical Scientists, 2010
    • Certificate of Appreciation, Alfred P. Sloan Foundation, Advancing Underrepresented Minority Students in STEM Disciplines, 2007
    • G.E. Philbrook Award for Undergraduate Teaching, Northeast Georgia Chapter of the American Chemical Society, 2005
  • Affiliations
  • Research Interests

    Dr. Bartlett’s lab research centers around applications of analytical chemistry to study biological problems. Currently, he and his team are studying the absorption, distribution, metabolism and excretion (ADME) of drug substances and environmental toxicants with the goal of developing novel methods to address significant questions in the biomedical sciences. In collaboration with Dr. James Bruckner, they aim to provide realistic risk assessments for common environmental contaminants. Furthermore, in collaboration with Dr. Alvin V. Terry at the Medical College of Georgia (MCG), they also study many compounds shown to affect memory and cognition, and have developed several highly sensitive assessments to determine overall impact on the brain.

  • Selected Publications

    Babak Basiri, Hilde van Hattum, William D. van Dongen, Mandi M. Murph and Michael G. Bartlett*, “The role of fluorinated alcohols as mobile phase modifiers for LC-MS analysis of oligonucleotides.” Journal of the American Society for Mass Spectrometry, 28, 190-199 (2017).; doi: 10.1007/s13361-016-1500-3 (IF2016=2.786)

    Xiangkun Yang, Yongjie Ma, Ning Li, Houjian Cai and Michael G. Bartlett*, “Development of a method for the determination of acyl-CoA compounds by liquid chromatography mass spectrometry to probe cell signaling activation.” Analytical Chemistry, 89, 813-821 (2017).; doi: 10.1021/acs.analchem.6b03623 (IF2016=6.320)

    Xian Wu, Xiangkun Yang, Anirban Majumder, Raymond Swetenburg, Forrest Goodfellow, Michael G. Bartlett and Steven L. Stice*, “Astrocytes are neuroprotective against chlorpyrifos developmental neurotoxicity in human pluripotent stem cell derived astrocyte-neuron co-cultures.” Toxicological Sciences, 157, 410-420 (2017).: doi: 10.1093/toxsci/kfx056 (IF2016=4.081)

    Jie Gao, Sean X. Naughton, Wayne D. Beck, Caterina M. Hernandez, Guangyu Wu, Xinagkun Yang, Michael G. Bartlett and Alvin V. Terry*, “Chlorpyrifos and chlorpyrifos oxon impair the transport of membrane bound organelles in rat cortical axons.” Neurotoxicology, 62, 111-123 (2017).: doi: 10.1016/j.neuro.2017.06.003 (IF2016=3.100)

    Sungjin Kim, Xiangkun Yang, Qianjin Li, Meng Wu, Leah Costyn, Zanna Beharry, Alicja Bielawska, Michael G. Bartlett and Houjian Cai*, “Myristoylation of Src kinase mediates Src-induced and high-fat diet accelerated prostate tumor progression in mice.” Journal of Biological Chemistry, 292, 18422-18433 (2017).: doi: 10.1074/jbc.M117.798827 (IF2016=4.125)

    Mona H. Abdel-Rahman, Darren R. Gullick, Joshua Hoerner and Michael G. Bartlett*, “Determination of the genotoxin impurities monomethylsulfate and dimethylsulfate in active pharmaceutical ingredients.” Analytical Methods, 9, 1112-1118 (2017).: doi: 10.1039/C7AY00044H (IF2016=1.900)

    Babak Basiri, Mandi M. Murph and Michael G. Bartlett*, “Physiochemical parameters that influence the electrospray desorption process for oligonucleotides.” Journal of the American Society for Mass Spectrometry, 28, 1647-1656 (2017): doi: 10.1007/s13361-017-1671-6 (IF2016=2.786)

    Zhen Han, Chau-wen Chou, Xiangkun Yang, Michael G. Bartlett, Y. George Zheng*, “Profiling cellular substrates of lysine acetyltransferases GCN5 and p300 with orthogonal labeling and click chemistry.” ACS Chemical Biology, 12, 1547-1555 (2017): doi: 10.1021/acschembio.7b00114 (IF2016=4.995)

    Shirin Hooshfar, Darren R. Gullick, Michael R. Linzey, Tanzir B. Mortuza, Mona H. Abdel-Rahman, Clinton A. Rogers, James V. Bruckner, Catherine A. White and Michael G. Bartlett*, “Simultaneous determination of cis- and trans-permethrin from rat plasma and brain tissue by gas chromatography negative ion chemical ionization mass spectrometry.” Journal of Chromatography B, 1060, 291-299 (2017): doi: 10.1016/j.jchromb.2017.06.019 (IF2016=2.603)

    Shirin Hooshfar, Tanzir B, Mortuza, Clinton A. Rogers, Michael R. Linzey, Darren R. Gullick, James V. Bruckner, Catherine A. White and Michael G. Bartlett*, “Negative chemical ionization gas chromatography mass spectrometry of transfluthrin in rat plasma and brain.” Rapid Communications in Mass Spectrometry, 31, 1573-1581 (2017): doi: 10.1002/rcm.7942 (IF2016=1.998)

    Xiangkun Yang, Xian Wu, Kyle A. Brown, Thao Le, Steven L. Stice and Michael G. Bartlett*, “Determination of chlorpyrifos and its metabolites in cells and culture media by liquid chromatography electrospray ionization tandem mass spectrometry.” Journal of Chromatography B, 1063, 112-117 (2017): doi: 10/1016/j.chromb.2017.08.010 (IF2016=2.603)

    Shirin Hooshfar and Michael G. Bartlett*, “Hazards in chromatographic bioanalytical method development and applications.” Biomedical Chromatography, 31, e3859 (2017).; doi: 10.1002/bmc.3859 (IF2016=1.613)

    Shirin Hooshfar and Michael G. Bartlett*, “Bioanalytical methods for the quantification of cis and trans permethrin.” Bioanalysis, 9, 1433-1435 (2017).: doi: 10.4155/bio-2017-0157 (IF2016=2.673)

    Michael G. Bartlett, Babak Basiri, Ning Li. Chapter 26, pgs. 407-423: Quantitation of RNA Biomarkers; In Targeted Biomarker Quantitation by LC-MS; Wiley-Blackwell (2017).

    Basiri B, Murph MM, Bartlett MG*. (2017) Assessing the Interplay between the Physicochemical Parameters of Ion-Pairing Reagents and the Analyte Sequence on the Electrospray Desorption Process for Oligonucleotides. J Am Soc Mass Spectrom. 2017 Apr 12. PMID: 28405940. (IF2016: 2.786)

    Babak Basiri, J. Michael Sutton, Brad S. Hanberry, Jason A. Zastre and Michael G. Bartlett*, “Ion-pairing liquid chromatography method for the determination of thiamine homeostasis.” Biomedical Chromatography, 30, 35-41 (2016).; doi: 10.1002/bmc.3544

    Shirin Hooshfar, Babak Basiri and Michael G. Bartlett*, “Development of a surrogate matrix for cerebral spinal fluid for LC/MS based analytical methods.” Rapid Communications in Mass Spectrometry, 30, 854-858 (2016).; doi: 10.1002/rcm.7509

    Darren R. Gullick, James V. Bruckner, Catherine A. White, Chen Chen, Brian S. Cummings and Michael G. Bartlett*, “Quantitation of deltamethrin in rat liver and muscle homogenates using dispersive solid phase extraction and gas chromatography-negative chemical ionization mass spectrometry.” Journal of the AOAC International, 99, 813-820 (2016).; doi: 10.5740/jaoacint.15-0314

    Jaeah Kim, Christopher P. Hopper, Kelsey H. Connell, Parisa Darkhal, Jason A. Zastre and Michael G. Bartlett*, “Development of a novel method for the bioanalysis of benfotiamine and salbutiamine for the determination of their impact on cancer cell proliferation.” Analytical Methods, 8, 5596-5603 (2016).; doi: 10.1039/c6ay01387b

    Xiangkun Yang and Michael G. Bartlett* (2016), “Identification of protein adduction using mass spectrometry: Protein adducts as biomarkers and predictors of toxicity mechanisms.” Rapid Communications in Mass Spectrometry, 30, 652-664.; doi: 10.1002/rcm.7462

    Darren R. Gullick, Kyle B. Mott and Michael G. Bartlett*, “Chromatographic methods for the bioanalysis of pyrethroid pesticides.” Biomedical Chromatography, 30, 772-789 (2016).; doi: 10/1002/bmc.3712

    Pei Li, Wayne D. Beck, Patrick M. Callahan, Alvin V. Terry and Michael G. Bartlett, “Pharmacokinetics of cotinine in rats: a potential therapeutic agent for disorders of cognitive function.” Pharmacological Reports, 67, 494-500 (2015).

    Pei Li, Zi Li, Wayne D. Beck, Patrick M. Callahan, Alvin V. Terry, Maor Bar-peled and Michael G. Bartlett, “Biogeneration of stable isotope-labeled internal standards for absolute and relative quantitation of phase II drug metabolites using LC-MS/MS” Analytical and Bioanalytical Chemistry, 407, 4053-4063 (2015).

    Xisheng Yan, Dylan W. Maixner, Ruchi Yadav, Mei Gao, Pei Li, Michael G. Bartlett and Han-rong Weng, “Paclitaxel induces acute pain via directly activating spinal TLR4” Molecular Pain, 11, 10 (2015).

    Xiangkun Yang, Indrani Poddar, Caterina M. Hernandez, Alvin V. Terry, Michael G. Bartlett, “Simultaneous quantitation of quetiapine and its active metabolite norquetiapine in rat plasma and brain tissue by high performance liquid chromatography / electrospray ionization tandem mass spectrometry (LC-MS/MS).” Journal of Chromatography B, 1002, 71-77 (2015).

    Buyun Chen, Guanhua Chen, Michael G. Bartlett (2014) “Factors influencing the electrokinetic injection of oligonucleotides in capillary gel electrophoresis when using laser induced fluorescence detection.” Biomedical Chromatography, 28, 320-323.

    Darren Gullick, Andrew Popovici, Holly C. Young, James V. Bruckner, Brian S. Cummings, Pei Li and Michael G. Bartlett (2014) “Determination of deltamethrin in rat plasma and brain tissue using gas chromatography-negative chemical ionization mass spectrometry.”Journal of Chromatography B, 960, 158-165.

    Babak Basiri and Michael G. Bartlett, (2014) “Liquid chromatography mass spectrometry of oligonucleotides: Applications in biomedical research.”  Bioanalysis, 6, 1525-1542.

    Pei Li and Michael G. Bartlett (2014) “A review of quantitative methods for small molecules in brain tissue by liquid chromatography tandem mass spectrometry.” Analytical Methods, 6, 6183-6207.

    B. Chen, S.F. Mason and M.G. Bartlett, “The Effect of Organic Modifiers on the Electrospray Ionization Charge-State Distribution and Desorption Efficiency for Oligonucleotides.” Journal of the American Society for Mass Spectrometry, 24, 257-264 (2013).

    B. Chen and M.G. Bartlett, “Evaluation of mobile phase composition for enhancing sensitivity of targeted quantification of oligonucleotides using ultra-high performance liquid chromatography and mass spectrometry (UHPLC-MS/MS): Application to phosphorothioate DNA.” Journal of Chromatography A, 1288, 73-81 (2013).

    J.A. Zastre, B.S. Hanberry, R.L. Sweet, A.C. McGinnis, K.R. Venuti, M.G. Bartlett and R. Govindarajan, “Up-regulation of Vitamin B1 Homeostasis Genes in Breast Cancer.”Journal of Nutritional Biochemistry, 24, 1616-1624 (2013).

    P. Li, B.J. Albrecht, X. Yan, M. Gao, H-R. Weng, M.G. Bartlett, “A rapid analytical method for the quantification of paclitaxel in rat plasma and brain tissue using high performance liquid chromatography tandem mass spectrometry.”  Rapid Communications in Mass Spectrometry, 27, 2127-2134 (2013).

    A.C. McGinnis, B.S. Cummings and M.G. Bartlett, “Ion exchange liquid chromatography method for the direct determination of small ribonucleic acids.”  Analytica Chimica Acta, 799, 57-67 (2013).

    A.C. McGinnis, E.C Grubb and M.G. Bartlett, “Systematic optimization of ion-pairing agents and hexafluoroisoproponal for enhanced electrospray ionization mass spectrometry of oligonucleotides.” Rapid Communications in Mass Spectrometry, 27, 2655-2664 (2013).

    M.G. Bartlett, B. Chen, A.C. McGinnis, Chapter 48: Liquid Chromatography Mass Spectrometric Bioanalysis of Oligonucleotides; In The Handbook of LC-MS Bioanalysis; Wiley-Blackwell, November 2013, ISBN: 9781118159248.

    A.C. McGinnis, B. Chen and M.G. Bartlett, “Chromatographic Methods for the Determination of Therapeutic Oligonucleotides.”  Journal of Chromatography B, 883-884, 76-94 (2012).

    A.V. Terry, J.J. Buccafusco, R. Schade, L. Vandenhuerk, P.M. Callahan, W.D. Beck, E.J. Hutchings, J.M. Chapman, P. Li and M.G. Bartlett, “The Nicotine Metabolite, Cotinine, Attenuates Glutamate (NMDA) Antagonist-related Effects on the Performance of the Five Choice Serial Reaction Time Task (5C-SRTT) in Rats.” Biochemical Pharmacology, 83, 941-951 (2012).

    B. Chen and M.G. Bartlett, “Determination of Therapeutic Oligonucleotides Using Capillary Electrophoresis.”  Biomedical Chromatography, 26, 409-418 (2012).

    F. Liang, A.V. Terry and M.G. Bartlett, “Determination of Aripiprazole in Rat Plasma and Brain Using Ultra Performance Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry.”  Biomedical Chromatography, 26, 1325-1332 (2012).

    P. Li, W.D. Beck, P.M. Callahan, A.V. Terry and M.G. Bartlett, “Quantitation of Cotinine and its Metabolites by Hydrophilic Interaction Chromatography Tandem Mass Spectrometry.”Journal of Chromatography B, 907, 117-125 (2012).

    B. Chen and M.G. Bartlett, “A One Step Solid Phase Extraction Method for the Bioanalysis of a Phosphorothioate Oligonucleotide and its 3’ n-1 Metabolite From Plasma Using UHPLC-MS/MS.”  AAPS Journal, 14, 772-780 (2012).

    H. Yi, H-J. Cho, S-M. Cho, D-G. Lee, A.M. Abd El-Aty, S-J. Yoon, G-W. Bae, K. Nho, B. Kim, C-H. Lee, J-S. Kim, M.G. Bartlett and H-C. Shin*, “Pharmacokinetic Properties and Anti-tumor Efficacy of a 5-Fluorouracil Loaded PEG-Hyrdogel.” BMC Cancer, 10, 211 (2010).

    A.V. Terry*, D.A. Gearhart, A. Pillai, G. Zhang and M.G. Bartlett, “Chronic antipsychotic treatment: protracted decreases in phosphor-TrkA nerve growth factor receptor levels in the rat hippocampus.” International Journal of Neuropsychopharmacology, 13, 799-805 (2010).

    M.K. Altman, V. Gopal, W. Jia, S. Yu, H. Hall, G.B. Mills, C. McGinnis, M.G. Bartlett, G. Jiang, D. Madan, G.D. Prestwich, Y. Xu, M.A. Davies and M.M. Murph*, “Targeting Melanoma Growth and Viability Reveals Dualistic Functionality of the Phosphonothioate Analogue of Carba Cyclic Phosphatidic Acid.” Molecular Cancer, 9, 140 (2010).

    H. Yi, M-J. Shin, S-M. Cho, D-G. Lee, K. Cho, H-J. Cho, S-J Shin, M.G. Bartlett, J-S. Kim and H-C. Shin*, “Nonlinear Toxicokinetics of Enrofloxacin in Rats.” Archives of Pharmaceutical Research, 33(11), 1851-1857 (2010).

    A.V. Terry*, J.J. Buccafusco, D.A. Gearhart, W.D. Beck, M-L. Middlemore, J.N. Truan, G.M. Schwarz, M. Xu, M.G. Bartlett, A. Kutiyanawallaa, A. Pillai, “Repeated, Intermittent Exposures to Diisopropylfluorophosphate in Rats: Protracted Effects on Nerve Growth Factor-Related Proteins, Cholinergic Markers, and Cognitive Function.” Neuroscience,176, 237-253 (2011).

  • Grant Support
    • Council for the Advancement of Pyrethroid Human Risk Assessment
    • National Institutes for Health (R21 AA021948)
    • National Institutes for Health (R01 CA172495)
    • National Institutes for Health (R15 CA176653)
    • American Cancer Society