Principal Investigator: Dr. Lakshman Segar
Our ongoing research is aimed at understanding the molecular mechanisms of atherosclerosis and fatty liver disease. Atherosclerosis is characterized in part by accumulation of lipids (e.g., cholesterol) in the arterial wall and phenotypic changes in vascular smooth muscle cells (VSMCs). Fatty liver disease, also referred to as hepatic steatosis, is characterized by accumulation of lipids in the form of droplets (e.g., triglycerides) in hepatocytes. The primary focus of our lab is to investigate altered growth factor signaling in VSMCs and dysregulated fatty acid metabolism in hepatic tissues in metabolically compromised conditions such as obesity, diabetes, and dyslipidemia.