The UGA Drug Discovery Core Lab was established to develop a sustainable, interdisciplinary, externally- funded Drug Discovery research resource by assembling existing chemical, biological, and pharmaceutical resources and expertise on campus.

The DDC lab will provide the UGA biomedical research community with access to chemical libraries, expertise and instrumentation for high throughput screening and pre-clinical assessment of drug candidates. Specifically, the proposed Consortium will:

  • Provide curation, management, and distribution of chemical libraries.
  • Perform High throughput screening (HTS) to identify novel lead compounds using investigator-developed assays.
  • Assess toxicity and “drug likeness” of lead compounds to facilitate advancement to clinical development.
  • Chemical Libraries

    Chemical libraries with 50,000+ compounds:
    Diversity sets
    Natural products
    Targeted libraries

  • Screening

    Activity-based and phenotypic screening
    96 and 384 well format robotic liquid handling
    Integrated multi-modal plate reader

  • Toxicity & PK

    Cytotoxicity screening in cancer, kidney and liver cells
    In vitro metabolism
    Physiochemical compound characterization

  • Resources & Services

    Commercial chemical libraries with 50,000+ compounds
    Library curation, database management, and daughter plate distribution
    Activity based high throughput screening.
    Tecan Freedom EVO100, Liquid handling robot with MCA9 arm and integrated multi-modal plate reader
    Cytotoxicity screening
    Physiochemical compound characterization

  • Sponsors

    UGA College of Pharmacy
    UGA College of Veterinary Medicine
    UGA Office of Research
    Center for Tropical and Emerging Diseases
    Department of Cell Biology
    Department of Pharmaceutical and Biomedical Sciences

  • Steering Committee

    Shelley Hooks
    Brian Cummings
    Kojo Mensa-Wilmot
    Stephen Trent
    Scott Pegan
    Dennis Kyle
    Belen Cassera