David Crich, DèsSc

Pharmaceutical and Biomedical Sciences
Professor
Georgia Research Alliance and David Chu Eminent Scholar in Drug Design

Curriculum Vitae

Pharmaceutical and Biomedical Sciences

Education

Docteur ès Sciences, Organic Chemistry, Université de Paris XI – Orsay, France, 1984

B.Sc., Chemistry, University of Surrey, Guildford, UK, 1981

 

Honors, Awards, and Achievements

Académie des Sciences/Royal Society, Franco-British Prize, 1989

Royal Society of Chemistry, Corday-Morgan Medal, 1990

University of Illinois, University Scholar, 1992

Fellow of the A. P. Sloan Foundation, 1994

Royal Society of Chemistry, Carbohydrate Chemistry Award, 1994

Electronic Encyclopedia of Reagents for Organic Synthesis, Executive Editor, 2002-2009

Fellow of the Japan Society for the Promotion of Science, 2006

Honorary Doctor of Science, University of Derby, UK, 2007

American Chemical Society, Carbohydrate Division, Wolfrom Award, 2008

Electronic Encyclopedia of Reagents for Organic Synthesis, Editor in Chief, 2009-2015

American Chemical Society, Arthur C Cope Senior Scholar, 2011

European Carbohydrate Society, Emil Fischer Award, 2011

Royal Society of Chemistry, Haworth Memorial Lecturer and Medal, 2014

American Chemical Society, Carbohydrate Division, C. S. Hudson Award, 2017

International Carbohydrate Organization, Whistler Prize, 2018

Affiliations

American Chemical Society, Member

Research Interests

The Crich lab is an organic and medicinal chemistry group with diverse interests in drug design and development, synthetic methodology, and carbohydrate chemistry and biology.  Current projects include:

  1. The design, synthesis, evaluation, and development of novel anti-infective agents for the treatment of multidrug-resistant infectious diseases. Currently, this project emphasizes the development of novel aminoglycoside antibiotics with reduced toxicity for the treatment of ESKAPE pathogens.
  2. The design, synthesis and evaluation of glycomimetics with potential for use as novel therapeutic agents. The current goal is the exploration of small molecule analogs of the β-(1→3)-glucans for use as immunostimulants.
  3. The development of improved chemistry for the stereoselective synthesis of glycosidic bonds of all types. Emphasis is currently placed on the bacterial sialic acids, legionaminic and pseudaminic acid, with the goal of preparing otherwise difficulty accessible bacterial oligosaccharides for applications in glycobiology.
  4. The exploration of under-represented functional groups in medicinal chemistry with the aim of expanding chemical space and diversity.
Selected Publications

Wen, V. Větvička, and D. Crich*, Synthesis and Evaluation of Oligomeric Thioether-Linked Carbacyclic β-(1→3)-Glucan Mimetics, J Org Chem, 84, 5554-5563, 2019. IF = 4.745

A. Sarpe, M. G. Pirrone, K. Haldimann, S. N. Hobbie, A. Vasella, and D. Crich*, Synthesis of Saccharocin from Apramycin and Evaluation of its Ribosomal Selectivity, Med Chem Commun, 10, 554-558, 2019. IF = 2.394

Matsushita, G. C. Sati, N. Kondasinghe, M. G. Pirrone, T. Kato, P. Waduge, H. S. Kumar, A. Cortes Sanchon, M. Dobosz-Bartoszek, D. Shcherbakov, M. Juhas, S. N. Hobbie, T. Schrepfer, C. S. Chow, Y. S. Polikanov, J. Schacht, A. Vasella*, E. C. Böttger*, and D. Crich*, Design, Multigram Synthesis, and in Vitro and in Vivo Evaluation of Propylamycin: A Semisynthetic 4,5-Deoxystreptamine Class Aminoglycoside for the Treatment of Drug-Resistant Enterobacteriaceae and Other Gram-Negative Pathogens, J Am Chem Soc, 141, 5051-5061, 2019. IF = 14.695

Juhas, E. Widlake, J. Teo, D. L. Huseby, J. M. Tyrrell, Y. Polikanov, O. Ercan, A. Petersson, S. Cao, A. F. Aboklaish, A. Rominski, D. Crich, E. C. Böttger, T. R. Walsh, D. Hughes, and S. N. Hobbie*, In-vitro Activity of Apramycin Against Multidrug-, Carbapenem-, and Aminoglycoside-Resistant Enterobacteriaceae and Acinetobacter baumannii, J Antimicrob Chemother, 74, 944-952, 2019. IF = 5.113

Liao, V. Větvička, and D. Crich*, Synthesis and Evaluation of 1,5-Dithia-D-laminaribiose, Triose and Tetraose as Truncated β-(1→3)-Glucan Mimetics, J Org Chem, 83, 14894-14904, 2018. IF = 4.745

Dhakal and D. Crich*, Synthesis and Stereocontrolled Equatorially Selective Glycosylation Reactions of a Pseudaminic Acid Donor: Importance of the Side Chain Conformation, and Regioselective Reduction of Azide Protecting Groups, J Am Chem Soc 140, 15008—15015, 2018. IF = 14.695

O. Adero, H. Amarasekara, P. Wen, L. Bohé, and D. Crich*, The Experimental Evidence in Support of Glycosylation Mechanisms at the SN1-SN2 Interface, Chem Rev, 118, 8242-8284, 2018. IF = 54.301

Amarasekara, S. Dharuman, T. Kato, and D. Crich*, Synthesis of Conformationally-Locked cis- and trans-Bicyclo[4.4.0] Mono-, Di- and Trioxadecane Modifications of Galacto- and Glucopyranose. Experimental Limiting 3JH,H Coupling Constants for the Estimation of Carbohydrate Side Chain Populations and Beyond, J Org Chem 83, 881-897, 2018. IF = 4.745

Popik, B. Dhakal, and D. Crich*, Stereoselective Synthesis of the Equatorial Glycosides of Legionaminic Acid, J Org Chem 82, 6142-6153, 2017. IF = 4.745

Buda and D. Crich*, Oxidative Deamination of N-Acetyl Neuraminic Acid: Substituent Effects and Mechanism, J Am Chem Soc, 138, 1084-1092., 2016. IF = 14.695

O. Adero, T. Furukawa, M. Huang, D. Mukherjee, P. Retailleau, L. Bohé, and D. Crich*, Cation Clock Reactions for the Determination of Relative Reaction Kinetics in Glycosylation Reactions: Applications to Gluco- and Mannopyranosyl Sulfoxide and Trichloroacetimidate Type Donors, J Am Chem Soc, 137, 10336-10345, 2015. IF = 14.695

Huang, G. E. Garrett, N. Birlirakis, L. Bohé, D. A. Pratt, and D. Crich*, Dissecting the Mechanisms of a Class of Chemical Glycosylation Using Primary 13C Kinetic Isotope Effects, Nature Chemistry, 4, 663-667, 2012. IF = 23.193

Grant Support

National Institute of Aids and Infectious Diseases

National Institute of General Medical Sciences

Swiss National Science Foundation