Postdoctoral Fellow, Chemical Engineering, California Institute of Technology, Pasadena, CA

Ph.D., Pharmaceutical Sciences, University of Wisconsin-Madison, Madison, WI

B.S., Biomedical Engineering, Marquette University, Milwaukee, WI

Research Areas: Drug delivery and pharmaceutics, specifically the design of macromolecules to improve iron chelation therapy and strategies to
combat multi-drug resistance in bacteria
Opportunities for Collaboration: Any area in which drug delivery is a challenge

Wang Y, Liu Z, Lin TM, Chanana S, Xiong MP*. Nanogel-DFO conjugates as a model to investigate pharmacokinetics, biodistribution, and iron chelation in vivo , Int J Pharm, 2018; 538(1-2) 79-86. PMID 29341909

Liu Z, Purro M, Qiao J, Xiong MP*. Multifunctional polymeric micelles for combining chelation and detection of iron in living cells, Adv Healthc Mater, 2017 (ePub ahead of print June 2017). PMCID: PMC5587393. Paper was highlighted as an inside cover article. IF=5.11

Xiong MP, Purro M. Siderophore-polymer conjugates for increasing bacterial sensitivity to antibiotics. Provisional patent No. 62/379121 was filed August 24, 2016 by the Wisconsin Alumni Research Foundation.

Xiong MP, Zhi Liu, Wang Y. Redox responsive compositions and uses thereof. Provisional patent No. 62/061,008 was filed October 7, 2014 by the Wisconsin Alumni Research Foundation.

Xiong MP, Wang Y, Tu S. Liposome-encapsulated hydrogels for use in a drug delivery system. Final patent application published May 8, 2014: US2014/0127287.

Xiong MP, Kwon GS, Bae Y, Kataoka K. Compositions and methods for delivery of therapeutic agents. Final patent application published September 17, 2009: US2009/0232762.

Dr. Xiong is interested in biomaterial-based systems in the area of iron chelation therapy, biological metal sensors, and overcoming antibiotic drug resistance in Gram-negative bacteria. Her current research is supported by an NIH R01 grant focusing on the development of materials for chelation of transfusional iron overload.

Visit Dr. Xiong’s lab website at: xionglab.uga.edu.

Liu Z, Lin TM, Purro M, Xiong MP*. Enzymatically biodegradable-polyrotaxane deferoxamine conjugates for iron chelation, ACS Appl Mater & Interfaces, 2016; 8(39) 25788-25797. PMID: 27623539

Zhi Liu, Yan Wang, Max Purro, May P Xiong. “Oxidation-induced degradable nanogels for iron chelation”, Sci Rep, Feb 12;6:20923, 2016. (link)

San Zeng, Arvinder Kapur, Manish Patankar, May P Xiong. “Formulation, characterization, and antitumor properties of trans- and cis-citral in the 4T1 breast cancer xenograft mouse model”, Pharm Res, 32(8) 2548-2558 2015. (link)

Kapur A, Felder M, Fass L, Kaur J, Czarnecki A, Rathi K, Zeng S, Osowski KK, Howell C, Xiong MP, Whelan RJ, Patankar MS*. Modulation of oxidative stress and subsequent induction of apoptosis and endoplasmic reticulum stress allows citral to decrease cancer cell proliferation. Sci Rep, 2016; 6:27530. PMID: 27270209

Yan Wang, Sheng Tu, Dana Steffen, May P Xiong. “Iron complexation to histone deacetylase inhibitors SAHA and LAQ824 in PEGylated liposomes can considerably improve pharmacokinetics in rats”, J Pharm Pharm Sci, 17(4) 583-602, 2014. (link)

Yan Wang, San Zeng, Tien-Min Lin, Lisa Krugner-Higby, Doug Lyman, Dana Steffen, May P Xiong. “Evaluating the anticancer properties of liposomal copper in a nude xenograft mouse model of human prostate cancer: formulation, in vitro, in vivo, histology, and tissue distribution studies”, Pharm Res, 31(11) 3106-3119, 2014. (link)

Yan Wang, Sheng Tu, Anatoly Pinchuck, May P Xiong. “Active drug encapsulation and release kinetics from hydrogel-in-liposome nanoparticles”. J Colloid Interface Sci, 406: 247-255, 2013. (link)

San Zeng, May P Xiong. “Trilayer micelles for combination delivery of rapamycin and siRNA targeting Y-box binding protein-1 (siYB-1)”. Biomaterials, 34(28): 6882-6892, 2013. (link)