2008-2014   Ph.D. in Chemical Biology, Yale University

2003-2007 B.A. in Physical Chemistry, Worcester Polytechnic Institute.

Designing small-molecule drugs based on biological mechanisms.

ChemBioChem Journal

2021  Early Career Award in Chemical Translational Biology

Northeastern Association of Graduate Schools

2010-15 Outstanding Dissertation Award

Yale University

2015 2010-15 Outstanding Dissertation Award(Northeastern Association of Graduate Schools)
2009 Dox Fellowship in Recognition of Excellence in Academics and Research in Chemistry

Worcester Polytechnic Institute

2008 WPI Institute Fellowship (post-Baccalaureate year of research)
2007 WPI Major Qualifying Project Award
2007 WPI Salisbury Award
2006 ACS Analytical Chemistry Division Undergraduate Award
2006 3rd Place, WPI Graduate Research Achievement Award (as an undergraduate)
2005 Pfizer/Connecticut Business and Industry Association Research Fellowship
2004 Charles O. Thompson Scholar
2004 The General Chemistry Achievement Award

• My lab focuses on using data science and artificial intelligence (AI) to improve how we match the right treatments to the right patients, both in people and animals. We build tools that combine lab experiments, big clinical datasets, and machine learning to better understand why some patients respond to certain drugs while others do not. By working closely with the UGA College of Veterinary Medicine and Emory University’s Winship Cancer Institute, we study real patient and animal tumor samples to develop new ways to predict treatment success and speed up the process of bringing new drugs to the clinic.
• In addition to research, my lab plays a key role in the Precision One Health Initiative at UGA, where we provide data and AI expertise to connect human and veterinary health. I developed a Biomedical Data Science course that teaches students essential coding and data-analysis skills, even if they have no prior experience. Through hands-on projects with real biomedical data, students gain the tools they need to contribute to modern healthcare and research. By combining education and research, our goal is to train the next generation of scientists and clinicians to use AI to improve health for both people and animals.

1. Driscoll, P.F.; Douglass Jr., E.F.; et. al. “Photocurrent generation in noncovalently assembled multilayered thin films” Langmuir, 2008, 24, 5140
2. Douglass Jr., E.F.; et al. “The Effect of Electrode Roughness on the Capacitive Behavior of Self-Assembled Monolayers” Anal. Chem. 2008, 80, 7670.
3. Wang, T.; Douglass Jr., E.F.; et al. “A Fluorescent Turn-On Sensor for Methylglyoxal” J. Am. Chem. Soc. 2013, 135, 12429.
4. Douglass Jr., E.F.; et. al. “A Comprehensive Mathematical Description of Three-Body Equilibria” J. Am. Chem. Soc. 2013, 135, 6092.
5. Jakobsche, C.E.; Parker, C.G.; Tao, R.N.; Kolesnikova, M.D.; Douglass Jr., E.F.; et. al. “Exploring binding & effector functions of human antibodies using synthetic immunomodulator” ACS Chem. Bio. 2013, 8, 2404.
6. Parker, C.G.; Dahlgren, M.K.; Li, D.T.; Douglass Jr., E.F.; et al. “Illuminating gp120–Ligand Recognition through Computationally-Driven Optimization of Antibody-Recruiting Molecules” Chem. Sci. 2014, 5, 2311.
7. McEnaney, P.J.; Fitzgerald, K.J.; Zhang, A. X.; Douglass Jr. E.F.; et al. “Chemically Synthesized Molecules with the Targeting and Effector Functions of Antibodies” J. Am. Chem. Soc. 2014, 136, 18034.
8. Santori, F.R.; Huang, P.; VanDePavert, S.A.; Douglass Jr, E.F.; et al. “Identification of Natural RORγt Ligands that Regulate the Development of Lymphoid Cells.” Cell Metab. 2015, 21, 286-297.
9. Ding, H.; Douglass Jr., E.F.; et al. “Quantitative Assessment of protein activity in orphan tissue and single cells using the metaVIPER algorithm.” Nature Comm. 2018, 9, 1471.
10. Douglass Jr, E.F.; Vasciaveo, A.; Alvarez, M., Realubit, R.; Karan, C.; Califano, A. “PANGEA: a drug perturbation RNAseq database for clinical oncology”, in prep.