Dr. Jason Zastre Secures $1.8M R01 Grant to Study B1 Deficiencies in Aging Process

Dr. Jason Zastre, Associate Professor in Pharmaceutical and Biomedical Sciences and Interim Assistant Department Head for Graduate Education, has received a $1,842,220, RO1 five-year grant from the Department of Health and Human Services National Institutes for Health—National Institute for Aging for his research, “Implications of Metabolic Dysfunction during Thiamine Insufficiency.” 

Age-related vitamin B1 (also known as thiamine) insufficiency and subsequent hypometabolism can promote debilitating neurotoxicity and hallmarks of Alzheimer’s disease pathology. This application proposes to better understand the mechanism initiating neurological damage as a consequence of thiamine insufficiency. 

Dr. Zastre also studies the impact of vitamin B1 on cancer progression. 

According to Zastre, “The proposed research is relevant to public health and the NIH’s mission, because it is expected to increase our understanding of age-related neurodegeneration from a nutritional and etiological perspective, and will set the foundation for therapeutic approaches that limit progression and maintain cognitive health.”

For more information on Dr. Zastre’s work, read about his research.  

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